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J Ethnopharmacol 93:123132

In colorectal cancer cells, 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) downregulates the expression of SLC7A11 and decreases cysteine to result in ferroptosis (Zhang et al

This single structural quirk has an outsized functional consequence: it renders the molecule resistant to cleavage by standard cellular peptidases, which recognize alpha bonds

Furthermore, the expression of the water channels, AQP1 and AQP5, was increased in HUVECs, suggesting that a large amount of water loss and/or influx occurred in HUVECs [35]